marijuana and fatigue

Why Does Smoking Cannabis Make You Feel Tired?

Several studies could point towards a more complex link between cannabis and the feeling of tiredness experienced after smoking.

Every regular cannabis smoker has experienced drowsiness, lethargy, or a general lack of motivation after or while smoking weed. Many will shrug this off as the nature of a specific strain, while some may find these attributes desirable—especially if insomnia is an issue. Newly published research may point to excessive cannabis consumption as a cause of long-term feelings of drowsiness or laziness. For those choosing to use recreational cannabis to avoid the hangover or comedown of other drugs, this strategy may prove somewhat ineffective.


A strong indica strain will undoubtedly knock you down onto the sofa, where, let’s be honest, not a lot gets done. For a vast majority, this is a desirable trait, and the reason users choose indica strains to begin with. If you enjoy smoking cannabis and live an otherwise active lifestyle, then smoking will not suddenly make you lazy or lethargic for the long-haul. The answer to why marijuana makes us feel drowsy and in turn, less motivated, could actually come down to the way THC is absorbed and subsequently interacts with the neurotransmitter dopamine.


Published by The National Institute For Biotechnology Information, the following research points to an apparent reduction in dopamine levels as a result of excessive cannabis use. In summary, the study found that heavy smokers of cannabis, those who were borderline dependent, produced significantly less dopamine than that of non-smokers or light users.

Using a sample group of 19 frequent cannabis smokers and 19 non-smokers, this study stands out because, although similar tests have been undertaken before, none have included active smokers. Importantly, the frequent cannabis smokers had all admitted to suffering from psychotic-like symptoms when smoking, a sign of excessive use.

Michael Bloomfield, PhD stated that “After a period of time, your brain cells aren’t able to make as much tyrosine hydroxylase, an important enzyme that’s a key component in making dopamine”.

This stunting of chemical processes is a result of the way the cannabinoid THC interacts with our body’s natural endocannabinoid system.


With heavy THC consumption seemingly impacting dopamine levels, what does the release of dopamine mean to our bodies? Dopamine acts as a regulator for effort threshold—how much effort is required to complete a task and what the rewards are. Those with higher levels of dopamine are more likely to undertake functions that require energy. Dopamine also plays a role in giving us that “rewarding” feeling when taking part in pleasurable activities like sex, eating, and exercise. If the level of dopamine released during these activities is reduced, then it stands to reason that motivation to perform would also decrease.


Cannabis is a complex organism. Alongside key cannabinoids THC, CBD, and CBN, cannabis contains terpenes. These molecules provide the vast array of aromas we have come to love. More than that though, theorists suggest that terpenes work in unison with cannabinoids to boost or enhance the relative effect.

A 2011 study examined the impact of the terpene myrcene. Myrcene is known for giving cannabis a musky, mango-like aroma. Furthermore, myrcene was found to induce a hypnotic effect, as well as display muscle-relaxant properties. Combined with THC, these two compounds work in conjunction to make individuals feel tired. Previous studies have found similar attributes with the terpene linalool, although this time, linalool partnered with CBD to produce a drowsy effect.


Playing a potential role in reducing dopamine levels, what else can smokers expect THC to impact? Well, the answer may reside in the land of Nod. Anecdotal evidence from users would suggest we sleep better after smoking cannabis. Many have reported that we sleep so much better that the feeling of drowsiness can be hard to shake the morning after. With so many swearing by cannabis as a sleep aid, what scientific research is there to support this thesis?

Two studies, the first conducted in 1975 and more recently in 2004, delivered relatively inconclusive results. Both noted a decrease in REM sleep (rapid eye movement sleep phase), but our deep sleep phase remained roughly the same. It could be surmised that a reduction in REM sleep could result in the feeling of increased tiredness experienced the morning after smoking cannabis.

Both investigations have something in common—the vast number of variables yet to be explored. The results are still too inconclusive to draw a satisfactory conclusion. Instead, further studies will be needed, in which sample size, age of participants, strains smoked, and any previous medical issues, etc are taken into account. One thing is for sure; there does seem to be some correlation between smoking cannabis and the feeling of tiredness. The exact cause of this phenomenon is still unknown.


What does that mean for us? Well, for now, the usual rules apply. Enjoy cannabis as you usually would, while being aware that every user will experience symptoms differently. If you do find yourself having periods of drowsiness or lethargy the morning after smoking cannabis, then a few simple steps can be taken to counteract this.

These include selecting a strain with less THC, smoking less, and hydrating. And of course, exercise, a healthy diet, and good ole coffee can help shake the fatigue as well; be it a result of smoking weed or not.

Numerous users will have experienced drowsiness when smoking cannabis. Is this a natural reaction, or is there a long-term impact on our bodies?

Fatique & Medical Marijuana

Fatigue is a symptom of a disease or a condition in its own right.

Fatigue is generally characterized by mental and physical tiredness that limits a person’s ability to perform daily activities. Normally, fatigue is relieved by rest and sustenance. In healthy individuals, stimuli from the body is send to the brain, producing a feeling of tiredness, initiating shutdown, so the body can shore up energy supplies and allow recovery.

The exact underlying causes of Chronic Fatigue Disorder is still debated, but surely involves a combination of genetic, environmental, infectious and psychological factors.

“The first virtue in a soldier is endurance of fatigue; courage is only the second virtue.”

Medical Marijuana – Different Strains for Different Folk

Marijuana contains varying quantities of more than 400 compounds of therapeutic interest. The effects of different strains of Medical Marijuana is primarily due to bioactive compounds called Cannabinoids, which include THC, CBD and essential oils.

Some Cannabis varieties are known to be uplifting, while others produce a calming and sedating effect. On the surface, it would seem that fatigued individuals should not use a sedating strain. However, this is not always true. Calming strains may help in treating eating and sleeping disorders, which leads to improved energy, over the long haul. Uplifting varieties are indicated when a person has to perform, now.

“Our fatigue is often caused not by work, but by worry, frustration and resentment.”

— Dale Carnegie, Self Improvement Writer.

Many peer reviewed research studies and clinical trials find that; the Cannabinoids found in Medical Marijuana may relieve the following symptoms associated with fatigue.

Fatigue Conditions

  • Systemic exertion intolerance disease
  • Post-viral fatigue syndrome
  • Chronic fatigue immune dysfunction syndrome
  • Cell Powerhouse Mitochondria malfunction


  • Impaired memory / concentration
  • Physical or mental exertions cause extreme exhaustion
  • Unrefreshing sleep
  • Muscle deadness
  • Aches and pains
  • Sore throat, lymph nodes
  • Dizziness, balance problems or fainting
  • Allergies; foods, odors, chemicals, medications, or noise
  • Gastrointestinal disorders
  • Irregular sweating and body temperature
  • Visual disturbances
  • Depression or mood problems

MMJDOCTORONLINE Note: It is important to consider that some forms of Medical Marijuana can temporarily worsen symptoms in some individuals. It is best that a qualified person advise on the the right form, strain and dose of Medical Cannabis. We provide Cannabis Recommenations, 420 Evaluations and MMJ Cards, that allow patients access to the right medicine, from any Club or Dispensary in the State of California.

Medical Marijuana and Mitochondria

Mitochondrial diseases can be inherited or acquired, which contribute to many disorders neurological and neuromuscular disorders, including fatigue.

Dysfunctional Mitochondria, the cell’s powerhouse, fail to properly convert food molecules into the ATP, the primary fuel that makes the cells, and the body, GO.

Cannabis has been found to improve mitochondrial function in rodent models Cannabis has also been shown to provide relief from seizures and pain, which greatly assists in fatigue reduction. Therapeutic natural Cannabinoids indicated for mitochondrial disease patients include CBD, THC and THCa.

Marijuana Cannabinoids also hold the capacity to literally halt brain inflammation responsible for causing cognitive decline, neural failure, and brain degeneration, all of which contribute to fatigue.

See how medical cannabis can help you with Fatique. Research and Therapy. Efficacy of Medical Marijuana in Fatique.