Liposomal CBD Oil


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Liposomal CBD may enhance hemp extract—but is it worth the money? In this article, we explore this upcoming area of cannabis research, its uses and potential benefits The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils? Liposomal CBD supplements manufactured by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability.

Liposomal CBD – A Breakthrough in the CBD Industry or Waste of Money?

The liposome represents a closed phospholipid bilayer vesicular system. The ability of these systems to encapsulate both hydrophobic and hydrophilic drugs, along with their biocompatibility and biodegradability, makes liposomes attractive tools in the field of drug delivery. Liposomes benefits have led to their widespread use as delivery vehicles for anti-cancer molecules, diagnostics, and therapeutic agents.

Liposomal CBD offers increased bioavailability, better control, and limited toxicity than non-liposomal CBD products. Liposomal delivery significantly reduces cannabidiol breakdown by metabolic processes allowing more CBD to enter the bloodstream. As a result, lower doses of liposomal CBD products may help achieve the same effects as higher doses of non-liposomal options. However, liposomal cannabidiol research is limited, and we need more information about its safety and efficacy.

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CBD or cannabidiol is considered an incredibly versatile cannabinoid with potential soothing and relaxing properties. To date, experts believe cannabinoids and terpenes are the most promising compounds in Cannabis plants, especially Cannabis Sativa and Cannabis Indica. The medicinal use of cannabinoids may provide replenishing effects. Cannabis specialists attribute some well-being benefits to one cannabinoid, while other uses may come from a combination of cannabinoids isolated from the cannabis plant. Ongoing research of cannabinoids and terpenes reveal new potential benefits of these natural compounds for wellness.

Some people use raw (or unheated) phytocannabinoid components like cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA) to benefit their well-being. In contrast, others may use the heat treatment of the plant extract to convert carboxylic acid forms of these components to their decarboxylated versions like CBD or THC by removing a carboxyl group and releasing carbon dioxide (CO2).

To date, cannabinoids are in all cannabis preparations. These compounds of the cannabis plant as direct agonists may bind to cannabinoids receptors in the brain to produce their effects. Cannabinoid receptors are one of the three main components of the endocannabinoid system or ECS—a complex cell-signalling system. The ECS regulates a range of physiological, cognitive, and homeostatic functions, including immune function, discomfort, appetite, metabolism, energy balance, memory, mood, and neurogenesis.

Besides two types of cannabinoid receptors (CB1 and CB2 receptors), the ECS also consists of endogenous cannabinoids. Some of these include anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and metabolic enzymes including fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Endogenous cannabinoids may bind as agonists to cannabinoid receptors, which are widely distributed throughout the brain and have high concentrations in reward and pain-related neural circuits. As for phytocannabinoids, like CBD and THC, these compounds may interact with the ECS by binding to its receptors like endocannabinoids. They potentially impact the way the ECS functions.

Nowadays, medical professionals consider CBD a breakthrough in medicine as this compound, along with other cannabinoids and terpenes in the cannabis plant, shows great promise for aiding holistic well-being. Due to this, global research on the potential benefits and side effects of cannabinoids is ongoing. Scientists worldwide are working to create the most effective and safe compound, hoping it will work along with existing medications and potentially substitute some of them in the future.

Liposomal CBD is the novel format of CBD oil, which some experts believe to be more effective than other oral CBD products. Let’s check what the research says and determine whether it is worth the money or another publicity stunt.

What are Liposomes? Benefits of the Liposomal Delivery System

The Greek etymology of liposome is “lipos”, meaning fat and “soma”, which means body. Liposomes are microscopic spheres surrounding nutrients or medicine, supporting their absorption into the body. A liposome is a “bubble” that packages a drug to protect it from normal bodily processes like digestion. Liposomes typically use phospholipids—materials, which are the same molecules that make up the cell membranes of our body. Phospholipids can aid direct drug absorption and bypass regular digestive system functions. The liposomal delivery system was first coined in the 1960s to improve the delivery of vital nutrients and medicines into the body. Currently, this system is primarily used in cancer treatments and is considered one of the most scientifically advanced drug delivery methods on the planet.

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Specialists from the National Cancer Institute state that liposomes represent a drug preparation that contains the active drug inside tiny, fat-like particles. Due to its small size, it is easier for the body to absorb these particles, allowing more of the drug to get to the target area, such as a tumour. Moreover, liposomal drugs may have fewer side effects and work better than other drug forms. Experts in this field suggest that any substance can utilise the liposomal delivery system so long as the active compounds are encased in a tiny fatty vesicle. However, researchers state this method works best with fat-soluble substances or minerals.

CBD is fat-soluble and works excellent in liposomal form. This form of CBD delivery enhances its bioavailability, increasing its absorption level in the body’s cells, tissues, and organs. In this way, consumers get the most from their CBD.

Bioavailability of Liposomal CBD Products: Can Small Size Trick Metabolic Processes?

The bioavailability can be comparable to the efficiency of the drug as this term describes the relative fraction of the orally administered dose, which is absorbed into the bloodstream. In other words, bioavailability is the amount of drug or any other substance the body can actually “use”. Bioavailability is usually represented as a percentage and calculated by comparing a systemic exposure profile to a suitable reference product.

The bioavailability of any drug (or substance) depends on how you introduce it to the body. For example, intravenous drug administration provides 100% bioavailability as all of it enters the bloodstream. At the same time, when taking a substance orally or in any other way, bioavailability starts decreasing as metabolic and digestive processes break down the compounds we ingest.

When it comes to CBD, different methods of taking this cannabinoid provide different bioavailability rates. To date, oral CBD formulations like capsules, foods, and beverages are among the most popular ways to consume CBD. However, this form of cannabidiol has the lowest bioavailability compared to other delivery forms. On average, oral CBD products can provide us with 6-19% bioavailability. Digestive acids and enzymes destroy a large percentage of CBD before its absorption, allowing only a small amount of the product to get through the intestinal wall, where the liver metabolises it and eventually reaches the rest of the body.

The industry considers CBD vaping and smoking more efficient as, in such a case, CBD bypasses the digestive tract and liver, which allows it to be readily absorbed through the thin membranes lining the alveoli of the lungs where it goes directly into the bloodstream. Smoking and vaping CBD have a bioavailability of 31%, but vaping may be the less irritating inhalation form. Unlike vaping, smoking produces combustion by-products such as fluorene, pyrene, acrylonitrile, and acrylamide, which may irritate the lungs.

Sublingual CBD drops and sprays allow cannabidiol to be absorbed through the mucous membranes of the mouth and nose, bypassing metabolic and digestive processes and going straight to the bloodstream. The sublingual method is most effective with liquid products like oils or tinctures and can provide consumers with up to 35% bioavailability which is significantly better than just swallowing CBD. Holding the drops under the tongue for 20-30 seconds before swallowing may improve CBD absorption.

Topical cannabidiol products like CBD-infused creams, lotions, and balms have the lowest bioavailability rates as fat-soluble cannabidiol is repelled by the water-soluble layer of skin which acts as a barrier to absorption. However, transdermal CBD provides a slow and steady absorption of the cannabinoid into the body, allowing its entrance into the bloodstream and maintaining its consistent level in the blood.

What about liposomal CBD? This form of CBD increases the bioavailability and allows the cannabinoid to stay longer in the body beyond the metabolic processes giving it time to absorb into the bloodstream. A pilot study investigated liposomal cannabidiol delivery and compared it to non-liposomal CBD when individuals consume them orally. Study results demonstrated that 40% of the study participants who took the non-liposomal form of cannabidiol had CBD in their blood one hour after ingestion. In comparison, all of the patients (100%) who took the liposomal CBD had it in the blood after the same period. These results demonstrate that liposomal cannabidiol has significantly better bioavailability than its stand-alone form. Limited research exists on the improved bioavailability of liposomal CBD, although studies are ongoing.

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Liposomal CBD products may help cannabidiol bypass the digestive system, where its bioactive compounds break down or the body rejects them. Researchers state that compounds like cannabidiol need a little help getting into the bloodstream, and liposomes can handle this successfully. It’s necessary to invest more time and research to better understand the peculiarities of the physiological CBD components and how they function with liposomes on a molecular level. To date, CBD liposomes are a unique concept in the cannabidiol industry. Experts believe that hemp oil liposomes may become a significant boost to the overall cannabis industry and be a great way to ensure that natural hemp compounds deliver effectively and efficiently.

What is Liposomal CBD? Is it Worth The Money?

The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils?

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Liposomal cannabidiol is one of the most cutting-edge advancements when it comes to CBD products.

The CBD is placed in a microscopic “packaging,” called a liposome, that increases the bioavailability.

This means more of the CBD is available for your body to use.

Learn everything you need to know about liposomal CBD, including whether it’s right for you, in this article.

Table of Contents

What Is Liposomal CBD?

Liposomal cannabidiol, or liposomal CBD, refers to any CBD placed in liposomes before being packaged and sold.

The liposomes work to keep the CBD compound intact as it moves through your body, increasing bioavailability.

Bioavailability refers to the amount of a substance that’s able to go from the digestive tract to the blood, as well as the blood to the individual tissues.

Having a higher bioavailability makes a compound stronger and faster-acting.

What Are Liposomes?

Liposomes are microscopic “packaging,” that surrounds each individual molecule of a compound to protect it from normal bodily processes like digestion.

Liposomes are “sphere-shaped vesicles,” usually made of natural phospholipids — the molecules that make up our cell membranes — so they’re totally safe to ingest [1].

Liposomes are used for various medicines and vitamins to protect the compound from the point of ingestion all the way to absorption into the bloodstream. This doesn’t necessarily mean you’re getting 100% of the compound you’ve taken — your body almost always expels at least some of the compounds you ingest.

Note that not all medications can be liposomal. It works best with fat-soluble substances or minerals. CBD is fat-soluble and works great in liposomal form.

What Is Bioavailability?

The FDA defines bioavailability as an estimate of the fraction of the dose that is absorbed into the systemic circulation, a.k.a. the bloodstream.

Bioavailability is essentially the amount of a drug or other substance the body can actually “use.” It’s usually represented as a percentage.

The bioavailability of any substance depends on how it’s introduced to the body. Introducing a drug intravenously puts bioavailability at 100% because all of it enters the bloodstream.

When you take a substance orally or any other way, bioavailability can decrease due to the metabolic and digestive processes that are designed to break down the compounds we ingest.

Liposomes increase the bioavailability of CBD because they protect each CBD molecule from degrading during the digestion process. With the liposomal “packaging” around the compound, your body can take up more of the CBD inside rather than expelling some of it through urine or feces.

What Is The Bioavailability Of CBD?

It might shock you to learn that the bioavailability of most non-liposomal, oral CBD products is very low. CBD isn’t soluble in water, which can make it harder for your body to absorb the compound [2].

So, when you take a normal CBD gummy or tincture dose, a lot of the milligrams of CBD are filtered out during the metabolic process. This leaves the bioavailability of oral CBD at about 9% [2]. For inhaled CBD products like vapes or flowers, bioavailability is greater — around 31% after smoking CBD [3].

Regardless of whether you choose to switch to liposomal CBD, it’s good to understand the approximate bioavailability of the products you like so you can have a better idea of how many milligrams of CBD your body is actually able to use.

However, keep in mind that bioavailability refers to the amount of the drug your body has the availability to take up — not necessarily the amount that actually moves into your bloodstream.

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For instance, bioavailability can theoretically exceed 100%. That doesn’t mean your body would take up more than 100% of the drug that’s there, but rather that your body is available to move more than 100% of the drug into the bloodstream.

How Liposomal CBD Increases Bioavailability

Liposomal CBD increases the bioavailability of CBD by allowing the compound to stay in your system beyond the metabolic process, giving it time to absorb into your bloodstream, as we’ve covered.

The question is, how much of a difference do those liposomes really make?

A recent study compared liposomal and non-liposomal CBD, both taken orally [4]. Forty percent of the patients who took the non-liposomal CBD had CBD in their blood one hour after ingestion. One hundred percent of the patients who took the liposomal CBD had CBD in their blood after the same period.

While there are limited studies on the increased bioavailability of liposomal CBD, the science is already there. Liposomes have been used since the 1960s for increased efficacy of tons of drugs and vitamins, all for the same reason that it’s being used for CBD now.

Compounds that are not fat or water-soluble simply need a little help getting into the bloodstream, and liposomes accomplish that.

Is Liposomal CBD Right For Me?

Despite the obvious benefits of liposomal CBD in terms of increased bioavailability, it might not be right for everyone. Because the technology is relatively cutting-edge within the world of cannabis, liposomal CBD products can be pricey and hard to find.

It’s also true that liposomal CBD isn’t really necessary if you prefer to take very low doses.

If a 50 mg dose of CBD is equivalent to around 25 mg of liposomal CBD, but the liposomal version is three times the price, it makes more sense to just use the standard CBD oil and take twice as much.

However, if you take very high doses of CBD, the price of liposomal CBD might start to feel worth it so you can get more out of the CBD you’re purchasing.

In terms of risk or difference in experience, liposomes will not impact your CBD in any way other than bioavailability. Liposomes are completely natural and non-toxic, and they’re designed to be absorbed into your blood. The only difference you might notice is higher efficacy; no additional side effects will take place [5].

Liposomal CBD

Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects [1].

Highly effective

Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.

Science Based

Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.

Better efficacy

Our liposomes are essentially non-toxic and biologically degradable.

Why Liposoma’s Liposomal CBD?

CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products [2].

Liposomal CBD

To make sure that CBD arrives in the gut in its active form, a solution is to incorporate it in liposomes, which are small, carefully designed phospholipid vesicles that form very stable dispersions in water [3]. The phospholipids constitute a bilayer structure in which the CBD molecules can be safely kept dissolved, while at the same time they act as surfactants that help present them to the intestinal epithelial cells in the most optimal manner.

What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes.

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