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Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies

Affiliations

  • 1 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • 2 Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • PMID: 26349415
  • PMCID: PMC4894524
  • DOI: 10.1615/critrevoncog.2015013713

Free PMC article

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies

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Authors

Affiliations

  • 1 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • 2 Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • PMID: 26349415
  • PMCID: PMC4894524
  • DOI: 10.1615/critrevoncog.2015013713

Abstract

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation.

Figures

Identified molecular alterations leading to…

Identified molecular alterations leading to metastatic traits of osteosarcoma cells. This image depicts…

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the gen …

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