Can I Mix CBD Oil With Melatonin


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Thinking of taking CBD oil with Melatonin and need to understand the effects, dosage, and safety? Here's the guide you need – from the Prescription experts! There is a body of research to indicate that CBD oil and melatonin work synergistically to help people get better sleep, and they are considered safe to take together as a sleep aid.

Taking CBD Oil With Melatonin, Dosage, Effects, and Safety

Have you ever just laid in bed and stared at the ceiling for what seems like hours trying to go to sleep? You may be looking for supplements and methods for trying to get better sleep, making you question if you can take CBD oil with melatonin.

In this article, we’ll answer your questions regarding the use of CBD oil and melatonin, the dose, the potential effects, and compatibility. First, let’s start with a quick summary.

Can I take CBD oil with melatonin? CBD oil and melatonin are considered safe to take together. They have sleep benefits that complement each other, especially for insomnia. Take a 1-mg melatonin tablet, split it into two and take half each night. Combine with 10mg of CBD oil or take 0.25/0.50 mg for every one pound weight as a guide.

Keep this quick answer in mind as we get into more of the specifics and other considerations to take into account.

Medication tips

To begin with, the following is a brief explanation of available research and information.

It’s important to clarify that both CBD oil and melatonin together can interact with other medications you may be taking. So, before following any of the proceeding information, we suggest you look to obtain your doctor’s consent.

The doses of either CBD oil or melatonin can vary if you’re taking them together for a night of better sleep.

In general, the dosage will depend on an array of factors such as age, weight, severity of insomnia, and other health conditions you may be experiencing. More on dosage shortly.

There is still no solid validity or reliability that taking CBD oil and melatonin together helps better sleep. So, only your doctor or relevant health professional can guide you on what’s good for you and your condition.

How CBD oil and melatonin work

In order to understand more about how these elements work together, let’s recap on both components.


Melatonin, in simple terms, is a hormone made by the pineal gland. It helps your body know when it’s time to sleep and wake up.

In other words, this hormone plays a crucial role in regulating your sleep-wake-up cycle, also known as the circadian rhythm.

Normally, your body makes more melatonin at night. The production of this hormone starts after sunset and reduces in the morning. Being exposed to harsh light in the late evening or at night can block melatonin production.

The production of melatonin in the body is commonly affected by factors such as age and exposure to artificial light.

This is especially relevant to current generations as they are regularly exposed to artificial light through phones, tablets, and computers. Therefore, melatonin production is treating affected.

The result of having insufficient melatonin production is insomnia or other sleep-related problems.

This is why many people will use melatonin supplements to treat their sleep problems.

These supplements work by activating the melatonin receptors in the brain, known as MT1 and MT2 receptors.

These receptors are the ones that inform or send signals to your brain that it’s time to sleep. Also, melatonin helps with the following as well:

  • Alleviating jet lag
  • Treating insomnia efficiency and quality
  • Minimizing the times you wake up during your sleep
  • Reducing sleep latency
  • Balancing the sleep cycles for people who go through complete or partial blindness

CBD oil

CBD oil, also known as cannabidiol, is a non-psychoactive extract of the cannabis plant. It’s a supplement that’s recently becoming more popular.

CBD oil is commonly used to help with anxiety, stress, mood swings, immunity, appetite, digestion, metabolism, inflammatory responses, insomnia, other sleeping disorders, and different chronic pains.

CBD oil works by interacting with the endocannabinoid system (ECS) through cannabinoid receptors found all over the body.

There are two types of endocannabinoid receptors; CB-1 and CB-2:

  • CB-1 receptors are more active in the central nervous system
  • CB-2 receptors are more active in the immune system

The ECS regulates many vital bodily functions, which help in maintaining balance within the body.

It’s through these receptors and interactions that CBD oil appears to be able to affect many of the body’s functions, including your sleep-wake cycles.

Connections between CBD oil and melatonin taken together

There is indeed a connection between CBD oil and melatonin.

Firstly, it’s that both have a strong positive impact on your sleep-wake cycle, especially helping with insomnia.

Secondly, the MT1 and MT2 melatonin receptors and CB-1 and CB-2 CBD receptors that influence sleep fall into the same group called G-protein coupled receptors.

This means they have a similar structure, process, and mechanism in which they influence the process of the sleep-wake cycle.

It’s this connection between CBD oil and melatonin that makes their benefits on sleep complement one other.

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Is taking CBD oil with Melatonin safe?

Further research is necessary to validate this statement, but in general, both are safe to take together.

Both elements present naturally beneficial effects on sleep, so taking them together can be more effective, especially for insomnia.

But as we always advise, consult your doctor before making any changes.

To support this further, melatonin reverses hormonal disruption triggered by external factors supporting faster sleep.

On the other hand, CBD oil can help alleviate anxiety and stress symptoms, supporting a night of quality sleep.

As such, both CBD oil and melatonin combined can offer you a more sustained level of quality sleep, with minimal waking patterns.

The right dose for taking CBD oil with melatonin

Although taking both together is generally considered safe, make sure you don’t overload sleeping substances.

This can make your day inactive and drowsy. Your dose should help you with a quality sleep at night to make sure you are alert, active, productive, and happy during the day.

When it comes to finding the right dose for taking CDB oil with melatonin, start with the lowest dose possible. And as directed by your doctor, gradually increase your dose until you feel the balanced effects.

With that being said, below, we’ve added a short guide for each CBD oil and melatonin dose that can help you with safe dosing.

Melatonin dosage

Melatonin is often sold in standard doses of 1-milligram tablets. So you can use this standard dose and split it into two nights.

Cut the tablet into two and take one half each night. Even a small dose of 0.3 to 0.5 milligrams is still effective, depending on your condition.

Some may require doses such as 5 mg, but they may come with some side effects such as headaches, nausea, weird dreams, and wooziness.

Now taking high doses of melatonin, especially anything higher than 5mg, is seen to be ineffective. So, taking a dose higher than 5mg will be unnecessary and is not worth the side effects.

CBD Oil dosage

The effects of CBD oil for sleep or insomnia are heavily dependent on the dose.

When taken in small amounts, it may act as a stimulant. However, taking large doses can induce sedation.

This is why figuring out the right dose is important with CBD oil.

The good news is that CBD has not been reported to have any adverse or fatal side effects. So, while you’re free to experiment, it’s advisory to keep it moderate as it can and does show mild side effects.

10 mg of CBD oil is a good starting point. Low doses of CBD oil can provide stimulating effects. As a general rule, consider 0.25 mg for every one pound of body weight. So, for an average 200-pound adult, 50 mg would be a guideline dose.

If you need a stronger dose, then consider 0.5 mg for every one pound of body weight. So again, for a 200-pound adult, that would be a dose of 100 mg to experience stronger effects.

Closing thoughts

We hope this has provided you with an overview of whether to take CBD oil with melatonin. As always, consult your doctor before making any potentially significant changes to your medications.

Can You Take CBD with Melatonin?

Both melatonin and CBD are often touted for their ability to help people fall asleep faster and stay asleep longer; with minimal side effects or safety concerns. For optimal effect, you may wonder if it’s safe and effective to combine the two sleep aids. And while it’s usually best to leave the combining of products to professionals like pharmacists and reputable manufacturers, you may find that using pre-existing products that contain both CBD and melatonin can help you enjoy even greater therapeutic benefits—including more restful sleep.

6 Benefits of Taking CBD and Melatonin

  1. Natural
  2. Available Over the Counter
  3. Easier to Fall Asleep
  4. Helps You Stay Asleep
  5. Reduces Anxiety
  6. Corrects Circadian Rhythm

Healthy sleep quality is absolutely essential to our optimal health and well-being, and according to the U.S. Centers for Disease Control and Prevention, roughly one third of Americans get less sleep than the recommended seven-hour minimum. But getting a natural sleep aid with high safety and efficacy may be easier than you think. Both CBD oil and melatonin have long been recognized for their abilities to help people fall asleep, stay asleep longer, and enjoy more restful, restorative sleep. And while for some people it might seem like a no-brainer to use products that combine the two, others may feel a bit of hesitation about combining supplements. But rest assured – as long as you’re using a product from a knowledgeable, reputable manufacturer that contains both CBD oil and melatonin, you should observe increased benefits with no negative side effects from your sleep aid.

As always, when adding a supplement to your health and wellness routine, it’s a good idea to talk with your doctor or pharmacist about potential benefits, side effects, and interactions with any other medications you may already be taking. You want to make sure you’re aware of any potential melatonin or CBD oil drug interactions .

Can You Take CBD with Melatonin?

There is a body of research to indicate that CBD oil and melatonin work synergistically to help people get better sleep, and they are considered safe to take together as a sleep aid. Melatonin is a naturally occurring hormone, produced by the pineal gland, that tells the body it is time to sleep. CBD also shows documented benefits that can translate to better sleep. However, the benefits of using the two active ingredients together seems greater than using either one on its own.

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The beauty of the synergy between CBD oil and melatonin is that the strength of each complements the other. But the way the two mix together is important. They need to be used in combination using exact ratios to get the greatest therapeutic effect. You can’t randomly mix together a CBD product and a melatonin product and expect to get good results. The concentration of both, along with the combination of additional cannabinoid compounds in the CBD oil, must be measured and dosed precisely to get the desired result. That’s why it’s best to use a product manufactured with both melatonin and CBD oil.

Melatonin affects the sleep wake cycle via regulation of both the melatonin 1a and melatonin 1b receptors—which are the main melatonin receptors in the human body. And while melatonin plays a vital role in regulating the sleep wake cycle, it will not necessarily put you to sleep effectively. Instead, the hormone’s main job is alerting the brain that it’s time to fall asleep. This is where CBD oil comes in as a sleep aid.

CBD is one of more than 100 powerful cannabinoid compounds naturally found within the cannabis sativa or hemp plant. And while melatonin may signal to your body that it’s time to go to sleep, CBD oil can help your brain activate the right neurotransmitters that help you stay asleep. This makes them a potent combination that helps you fall asleep and stay that way for a night of restful sleep.

Both the MT1 and MT2 melatonin receptors and the CB-1 and CB-2 CBD receptors that influence restful sleep are part of a category called G-protein-coupled receptors. They share a similar structure, process, and mechanism of action—which may explain why CBD oil and melatonin complement each other so well.

You can find CBD oil and melatonin hybrid products in many forms, including oils, tinctures, and gummy or CBD capsule forms. One of the most effective ways of using a sleep aid containing melatonin and CBD is to place a few drops of an oil or tincture under your tongue—this allows the active chemical compounds to bypass the digestive system and almost immediately be absorbed into your bloodstream. Many people who use a CBD/melatonin combo product this way report quickly falling into a light sleep, followed by moving into a deep REM cycle within an hour of using the product.

6 Benefits of Taking CBD and Melatonin

Let’s take a closer look at some of the chief benefits you may experience when using a product that combines CBD oil and melatonin.

1. Natural

Both CBD and melatonin are naturally occurring, meaning they exist independently in nature and are not formulated in a lab. By using a natural ingredient, like melatonin or CBD, rather than a pharmaceutically engineered sleep aid, you can avoid potential negative side effects, like excessive daytime sleepiness, sleepwalking, and even long-term dependency, which are often associated with prescription medication.

Neither CBD nor melatonin have been shown to have these side effects. And while certainly additional research is needed, all current indications are that CBD oil and melatonin are safe to take together since they interact with the body in different ways.

2. Available Over the Counter

Both CBD oil and a melatonin supplement are easily purchased without a prescription, making them much easier and quicker to access than pharmaceutical sleep medications, which are only available with a doctor’s prescription. Once you’ve spoken with your physician and decided to add a CBD sleep aid to your health and wellness routine, you can easily find one that meets your needs.

3. Easier to Fall Asleep

Since the body naturally produces melatonin, supplementing with additional melatonin often helps with insomnia and other sleep issues. Melatonin levels naturally rise in lower levels of light, which is why it’s common for people to start to feel sleepy when it gets dark at night. However, melatonin production can decrease as we age, making it harder to fall asleep on our own. Melatonin production can also be hampered by environmental factors. In particular, melatonin production can be inhibited by exposure to artificial light, such as those from televisions, computers, tablets, and smartphones. This represents a powerful influence over our melatonin levels given the amount of time our population spends in front of devices. Insufficient melatonin production can result in insomnia or other sleep issues, but supplementing with additional melatonin can help make sure you actually feel sleepy when you go to bed at night.

Note that a melatonin supplement won’t instantly knock you out—it simply prepares your brain and body to rest. Our normal production of melatonin usually begins to rise a couple of hours before it’s time to sleep, and it begins to decrease once we’ve been asleep around six hours, which signals the body that it’s time to move toward wakefulness. Combining melatonin with the natural relaxing power of a CBD product can make it that much easier to fall asleep.

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4. Helps You Stay Asleep

Many people have found that taking a melatonin supplement helps reduce the chances that they’ll wake up during the night. Additionally, a study published in the Journal of Psychopharmacology found that small doses of a CBD product increased total sleeping time for rats involved in the study, even during light periods of the day. CBD interacts with serotonin and GABA receptors in the brain, improving mood and decreasing anxiety, which leads to more restful sleep. And there’s early evidence to indicate that using CBD oil and melatonin together may be more effective at helping you stay asleep all night than using either product on its own.

5. Reduces Anxiety

CBD products have been shown to help reduce feelings of anxiety and stress, along with inducing a feeling of calm. Lowered stress levels and an overall sense of calm can aid in helping people relax, fall asleep faster and get more restful sleep throughout the night. When the nervous system relaxes, it can help your body and brain more readily enter the deepest and most restorative levels of quality sleep throughout the night.

6. Corrects Circadian Rhythm

One benefit associated with CBD is its ability to help people regulate their sleep wake cycle, also known as their circadian rhythm. Normally, a healthy circadian rhythm signals our bodies to be sleepy at night and alert during the day. If travel, stress, or other environmental factors cause the circadian rhythm to get interrupted or knocked off course, a CBD product often can help re-establish a healthy sleep wake cycle. In addition, because melatonin is the body’s key signal to the brain that it’s time to sleep or wake up, effective use of melatonin can help tremendously when it comes to regulating your circadian rhythm.

In the simplest of terms, a higher level of melatonin in the body signals that it’s time to sleep, while decreasing melatonin levels are a key signal to the body that it’s time to wake up. While melatonin engages with the melatonin 1a and 1b receptors, CBD interacts with CB-1 and CB-2 receptors, which help regulate both the immune system and the central nervous system. It’s through interaction with these receptors that CBD for sleep may also be able to influence and potentially help regulate the sleep wake cycle.

What is the Best Way to Mix CBD and Melatonin?

The best way to combine CBD and melatonin is to use an existing melatonin and CBD product from a manufacturer you know and trust. You should not try to combine a separate CBD product and melatonin supplement yourself at home. It’s important that each ingredient be blended in a proper ratio that allows it to complement the effects of the other. This is typically accomplished using high precision equipment, like those found in a laboratory.

For example, you might try Farmer and Chemist’s All Is Gel Melatonin Soft Gels . These CBD softgels combine 25 milligrams of CBD with one milligram of melatonin and offer a convenient, natural way to get quality sleep. Plus, you don’t have to worry about measuring dosages. The combination of CBD and melatonin can help both your mind and body relax and begin to move toward restfulness. In addition, these CBD softgels can help with pain relief and hold anti-inflammatory properties.

As always, when adding a supplement to your daily regimen, a good recommendation is to begin with the lowest possible dose and build gradually until you reach your desired level of therapeutic effect. When it comes to sleep aids, you want to find the dose that helps you fall asleep quickly, stay asleep longer, and experience the most restful sleep stages, while also making sure you avoid excessive daytime sleepiness or difficulty waking.

CBD and Melatonin Can Be the Key to a Restful Night of Sleep

Sleep problems are nothing to take lightly. They can lead to long-term, serious health conditions and should be addressed immediately. Using a product at night that combines CBD and melatonin can be an effective way to guarantee you’re getting high quality, restful sleep.

As always, it’s important to talk with a health professional when adding a CBD product to your wellness regimen. This is especially true if you’d like to combine CBD with melatonin, and even more crucial if you also take other medications on a regular basis. The pharmacists at Farmer & Chemist can be a tremendous resource. Our knowledgeable team can talk you through potential risks and benefits associated with CBD’s addition to your existing lifestyle, plus how CBD and melatonin combo products may help you improve your sleep quality.

Don’t put restful sleep off another night—check us out today and start experiencing the sleep benefits CBD products can provide!

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